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Figure 8 To conclude, macrocyclizations by oxidative disulfide formations in the N-terminal of Ang IV analogues or alternatively displacement of the disulfide unite with a trans double bond can provide very potent inhibitors of IRAP, as exemplified with 23 (HA08) comprising a 13-membered ring system and 28 , 30 , and 32 comprising 14-membered ring systems

European Journal of Pharmacology, 590(13), 246249

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The L1 penalty (LASSO regularization) contrasts with Ridge regression, which uses an L2 penalty